An unforgettable event needs an unforgettable venue. 21c Museum Hotel in downtown St. Louis brings a new kind of cultural and travel experience, setting a contemporary and artistic backdrop for every event on your wedding itinerary. Its grand design will take your breath away, all while still making you feel right at home. You'll escape the average and revel in the creativity of this historic, restored YMCA building, and you'll captivate your guests with its natural style that's enhanced by your own décor. 21c Museum Hotel St. Louis breaks away from the traditional, guaranteeing an unforgettable experience for everyone.